cleavable linker
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An ADC is a complex chemical entity containing a bio-macromolecule (the antibody) and one/several organic toxins (the payload) bridged by small molecular linkers, which dicate the release mechanism of the toxin once internalized. As one member of the cleavable linkers, pH-sensitive linkers (also refered to as acid-labile linekrs), such as hydrazones, are based on the a nonspecific pH sensing mechanism to achieve payload release.
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