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creative biolabs
  1. multipotent stem cells
  2. affinity of antibodies
  3. flow cytometry t cells
  4. Human Macrophage Culture
  5. Single Cell Omics strategies
  6. T Cell Reprogramming by mRNA
  7. mrna molecule
  8. Compound-specific Quinolones
  9. Fc-Fusion Protein Development
  10. Single Cell Omics for Immunity
  11. IVD Reagent develop for SARS-CoV-2
  12. phage display platform
  13. microfluidic develop
  14. Glycan Identification solutions
  15. anti bacteria
  16. Custom neuros in vitro assays
  17. Organotypic Brain Slice Models
  18. benefits of immune checkpoint inhibitors
  19. scaffold library
  20. Role of Ribosomes in MI
  21. anti pig antibody
  22. bacteria and antibodies
  23. Glycan Purification services
  24. Classically Activated M1 Macrophage
  25. neurotoxicity test
  26. how to dry emulsion quickly
  27. cell-based in vitro assays for live biotherapeutics
  28. Glycan Analysis
  29. Serum Glycoprotein Profiling
  30. parasite antibody discovery
  31. Haptens for Streptomycins
  32. biological indicator product
  33. antibodies targeting neuronal markers
  34. formulation of emulsion
  35. Non-IgG Antibody Related Diseases
  36. lung cancer biomarker
  37. lung cancer biomarker
  38. Liposome Immunization
  39. Odulimomab
  40. Custom iPS Cell Reprogramming by mRNA
  41. c reactive pro
  42. dopaminergic cell line
  43. In Vivo Neuroscience
  44. colorectal cancer probiotics
  45. liposomal formulation
  46. IgE antibody discovery
  47. antibody gif
  48. hpv antibody
  49. neural stem cells
  50. types of macrophages
  51. CTLA-4 Monoclonal Antibody
  52. γδ T Cell Development
  53. alzheimer's disease in vitro model
  54. phage manufacturing
  55. CLP model
  56. antibody internalization
  57. Single Cell Proteomics Platform
  58. monkeypox detection kit
  59. Rhesus Macaque MHC Genotyping
  60. Relative Abundance of Ribosomal Proteins
  61. Introduction of Cholesterol
  62. Astrocyte Markers
  63. Baboon Whole Blood
  64. alpha amanitin
  65. Ad fiber knob EPCAM Bibody
  66. cd11b marker
  67. Complement C3 Functional Test
  68. astrocytes
  69. γδ T Cell Subsets Based on Function
  70. Ad fiber knob EPCAM Fv IgG
  71. Cerebral Organoid Maturation Kit
  72. Scientists Use Lipid Nanoparticles to Precisely Target Gene-Editing Tools to the Lung
  73. New Insights Into the Pathogenesis and Diagnosis of Rheumatoid Arthritis
  74. Navigating the Post-Pandemic Era: Optimizing SARS-CoV-2 Antibody Responses
  75. ADCC/CDC Enhancement in Therapeutic Antibody Development
  76. Breast Cancer and Ribosomes: Unraveling the Intricacies of Cellular Processes
  77. Explore into Pharmacokinetics/pharmacodynamics (PK/PD) of Antibody Drugs
  78. Nonviral Tracers
  79. anti-WT1 CAR-T in vivo assay
  80. monkey splenocytes
  81. Cell Exosome Isolation
  82. stem cell assay
  83. Microorganisms
  84. PDX-derived Ovarian Cancer Organoid Model Introduction
  85. Anti-Hepatitis A Antibody Development Service
  86. Bleomycin-Induced Pulmonary Fibrosis Model
  87. complement inhibitors
  88. gba mutations in parkinson's disease
  89. adeno associated virus aav vectors in the cns
  90. Background of Gene Knockdown
  91. cleavable linker
  92. non-human primate (NHP) derived biospecimens provider
  93. Next-IO™ Anti-iNOS Therapeutic Monoclonal Antibody Program
  94. Activators & Inhibitors
Classically Activated M1 Macrophage {{ currentPage ? currentPage.title : "" }}

Introduction of M1 Macrophages

Macrophages play an important role in a wide variety of physiologic and pathologic processes. Plasticity and functional polarization are hallmarks of macrophages. As one of the two important subsets, M1 macrophages are typically induced by bacterial LPS or by some cytokines, such as Interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), and granulocyte-macrophage colony-stimulating factor (GM-CSF). M1 macrophages are characterized by high proinflammatory cytokine production, high chemokine (C-X-C motif) ligand 9 (CXCL9) production, and low levels of interleukin (IL)-10. Efficient M1 macrophage responses are important for ensuring resistance to bacterial infection. Many pathogens such as Brucella, Salmonella, and Mycobacterium have evolved mechanisms that interfere with M1 polarization. Conversely, excessive or unresolved M1 macrophage activation can cause chronic inflammation and tissue damage. Studies have shown that M1 macrophages are related to the pathogenesis of atherosclerosis, diabetes, and glomerulonephritis. In the nervous system, M1 macrophages have been associated with multiple sclerosis, amyotrophic lateral sclerosis, stroke, spinal cord injury, and traumatic brain injury.

M1 Macrophage Identification Service at Creative Biolabs

Identification of M1subsets at Creative Biolabs is usually carried out by quantification of M1 macrophage markers, including multiple cell surface markers, transcription factors, and cytokine profiles. IFN-γ, IL-1, IL-6, IL-10, IL-12, IL-23, TNF-α, CD16, CD32, CD64, CD68, CD80, CD86, CD369, inducible nitric oxide synthase (iNOS), signal transducer and activator of transcription 1 (STAT1), interferon regulatory factor 5 (IRF5), Mer tyrosine kinase (MerTK), class II major histocompatibility complex molecules (MHC class II), and CXCL9 are reliable markers for human M1 macrophages, while IFN-γ, IL-1, IL-6 IL-10,IL-12, IL-23, TNF-α, CD14, CD16, CD32, CD64, CD68, CD80, CD86, CD204, CD369, IRF5, MerTK, MHC II, and Ly-6C are often used for the identification of mouse M1 macrophages. Based on our powerful Macrophage Therapeutics Development Platform, our scientists are proficient at applying real-time PCR for transcriptional signature analysis, liquid chromatography-tandem mass spectrometry (LC-MS/MS) for proteome analysis, western blot (WB), immunohistochemistry (IHC), and flow cytometry (FC) for a comprehensive analysis of M1 macrophages.

Learn more: Classically Activated M1 Macrophage

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